The Fe3O4 nanoparticles were synthesized using the co-precipitation method. The synthesized Fe3O4 nanoparticles were incorporated into Chitosan (CS) based polymer matrix to generate the magnetic biocomposite (CS-MNP) catalyst. The nano biocomposite (CS-MNP) was characterized using different spectroscopic techniques such as FT-IR, XRD, SEM, TEM, DSC, and TGA analyses. Dihydropyrimidine (DHMP’s) derivatives using the Biginelli reaction were synthesized using the magnetic nanocomposite-based heterogeneous catalyst. This generated heterogeneous catalyst provided an effective yield and reduced the reaction time effectively. The most significant benefits of this technique for synthesizing DHMP derivatives are its catalyst reusability. The reused catalyst was characterized using the FTIR technique to understand the structure change and its efficacy. Therefore, an eco-friendly strategy was adopted to synthesize biologically active component dihydropyrimindine (DHMPs) derivatives efficiently.

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