Objectives: The aim of the present study was to prepare controlled porosity osmotic pump (CPOP) of indomethacin in order to reduce the dosing frequency and hence decrease side effect. So that it can Improve the therapeutic efficiency of indomethacin by maintaining constant plasma level over 12 hrs. Materials and Methods: Formulation were designed by preparation of controlled porosity osmotic tablet firstly, by direct compression then coating material was prepared and core tablets were coated using coating pan to get osmotically controlled release tablet. The controlled porosity osmotic drug delivery system consists of the core tablet containing drug and osmogenes along with other excipients and finally coated with polymer mixed with pore forming agent which is water soluble in nature. Results: The optimized formulation F-7 of osmotically controlled release tablet had shown 96.8% drug release in 12 hrs. Initially at 3 hrs drug relase was found to be 26.3% due to osmotic agent used. Conclusion: (F1-F10) indicates that the controlled porosity osmotic pump is suitable for delivery of indomethacin for more than 12 hours. The controlled porosity osmotic pump is cost effective technology along with reduced dosing frequency and increased patient compliance. The comparision of release profile of EOP with CPOP (F1-F10) indicates that the CPOP is suitable for delivery of indomethacin for more than 12 hours.It can be concluded that CPOP is ideal for the delivery of the drug where release of the drug is required to be for more than 12 hours.

Controlled, osmotic, Porosity, Indomethacin, coating